In 1988 Charles H. Khouri, M.D., an eye surgeon, went to Nashville, TN, to meet with old friends who wanted to venture into contact lens business. During lunch a professor of pharmacy mentioned that he invented a new compound with anti-inflammatory potential. He said that it was tested on hamsters with emphysema, a severe lung inflammation and scarring. Dr. Khouri wanted to test it on rabbit corneas with chemical burns..

Few months later the compound was tested on rabbit eyes. The compound reduced corneal inflammation and scarring. In 1992 it was given, as eye drops, to a human with a blind painful eye. Two weeks later the patient claimed that his hands’ arthritis, of six years, dramatically improved. It is well known that any eye drops goes into the system.

In November 1993, the compound was tested on a dog with spinal arthritis with secondary paraplegia. The dog started to walk in few weeks. A later a vet saw the video he told Dr. Khouri that even if the arthritis improved, the dog was NOT SUPPOSED TO WALK. He ADDED "this compound must have “DONE SOMETHING” to the damaged spinal nerves."