Effects of an Elastase Inhibitor On Rabbit Corneas

A novel drug, a human leukocyte elastase and protease inhibitor, with a molecular weight of less than 300, was tested on rabbit eyes. It seems to significantly reduce inflammation, scarring and new blood vessel formation in severe alkali burn.

The compound, a synthetic thio-carbamate, is dissolved in propylene glycol (one gram in one liter). The dosage was one drop in the eye 5 times a day.

Here are the slides:

The cornea after few minutes of bathing it with 1 Normal NaOH (control)

The cornea at the end of the second week (control)

The cornea is perforated at the end of third week (control)

The cornea during the fourth week. A blind eye. (control)

Complete corneal opacification. This eye will be treated with Elastase Inhibitor.

The limbus is starting to clear.

Three weeks after treatment. Significant changes.

The cornea THREE WEEKS after bathing with 1N NaOH for 30 seconds.
On placebo eye drops.

Four weeks on placebo. Notice fibro-vascular membrane.

Previous eye after 10 days of Rx with the Elastase Inhibitor. Healing began.

Four weeks on placebo and 17 days of treatment.

Reduced scarring & new blood vessel formation.

Inflammatory cells (PMNs) after 2 weeks on placebo.

Less inflammatory cells after 2 weeks of treatment.

This compound seems to work on other pathologic conditions. For more information, please go to http://www.qrparalysis.org/.

Or contact Charles H. Khouri, M.D.

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